Български |
Head of Laboratory Molecular Genetics | ||
| Interests: Genetics and epigenetics | |||
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| E-mail: miloshev@bio21.bas.bg Tel: (+359) 2 979 36 97 |
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| Name | George Angelov Miloshev |
| Address | Institute of Molecular Biology "Acad. R. Tsanev" Bulgarian Academy of Sciences (BAS) Molecular Genetics Lab “Acad. G. Bonchev” str., bl. 21, lab 523 1113 Sofia, Bulgaria |
| Telephone | (+359) 2 979 36 97 |
| miloshev@bio21.bas.bg |
| 2018 - present 2004 – 2018 |
Professor, Laboratory of Yeast Molecular Genetics, Institute of Molecular Biology “Acad. R. Tsanev”, BAS Associate professor, Head of Laboratory of Yeast Molecular Genetics, Institute of Molecular Biology “Acad. R. Tsanev”, BAS |
| 2004 - 2006 | Associate professor, Head of Department of Yeast Genetics, Institute of Molecular Biology “Acad. R. Tsanev”, BAS |
| 1994 - 2004 | Assistant professor and group leader with Department of Yeast genetics, at the Institute of Molecular Biology, BAS |
| 1999 - 2000 | Visiting scientist at Prof. Sarri Penings’s Lab, Department of Molecular Medicine, Edinburgh University, Edinburgh, UK |
| 1996 - 1997 | Visiting scientist at Prof. James Allan’s Lab, Department of Biochemistry, Edinburgh University, Edinburgh, UK |
| 1994 | PhD in Molecular Biology Thesis title: “Histone H1 and the chromatin of yeast Saccharomyces cerevisiae” |
| 1991 - 1994 | PhD student - Institute of Molecular Biology |
| 1984 - 1991 | Research assistant at the Department Chromatin, Institute of Molecular Biology, BAS |
| 1978 - 1983 | MSc student in Molecular biology and Genetics, in Department of Genetics, Faculty of Biology, Sofia University “St. Kl. Ohridski” |
| 2017 - 2020 | NATO Partner country director for NATO SPS MYP Project G5266 Field detector for genotoxicity by CBRN and explosive devices |
| 2016 - 2019 | Leader of the molecular genetics part of the project with Bulgarian Science Fund – Molecular mechanisms of immune tolerance - importance for endocrine function of regulatory T-cells |
| 2010 - 2013 | Leader of the molecular genetics part of the project with Bulgarian Science Fund – Study of mechanisms by wich Fragile X mental retardation protein 1 regulates neurodevelopment in Drosophila. Grant number DID 02-35 |
| 2010 - 2013 | Leader of the molecular genetics part of the project with Bulgarian Science Fund – Study of the effect of environmental pollution on the ionome of natural populations of dandelion for monitoringpurposes. Grant number DVDU 02/61 |
| 2010 - 2013 | Leader of the molecular genetics part of the project with Medical University – Plovdiv - YKL-40 – a fundamental and clinical study. Grant number НО - 1/ 2010 |
| 2009 - 2012 | Leader of the molecular genetics part of the project with University of Forestry, Sofia – Analysis of DNA damage in indicator plant species from threatened with pollution regions. Grant number 39/13.04.2009 |
| 1995 - 1996 | Research Project with Bulgarian Science Fund – Signals used for polyadenylation in the histone mRNAs of Saccharomyces cerevisiae. |
| 2005 – 2006 | Research project at the Bulgarian Science Fund – Optimization of a novel test for detection of DNA damaging agents in food; Grant number: MU - B-1512/05, “Young Scientists’ Call”, Section Biology |
| 2004 – 2006 | Research project at the Bulgarian Science Fund - Molecular markers in plant taxonomy – application of the RAPD method in the taxonomic study of Galanthus L. in Bulgaria; Grant number: MU - B -1407/04, Section Biology |
| 2008 – present | Lectures and practicals of MSc degree Molecular Biology students in the summer semester courses “Apoptosis as a norm and in pathology” at the Department of Cytology, Faculty of Biology, Sofia University |
| 2007 | Lectures and practicals for MSc degree students at Plovdiv University “P. Hilendarski” on “Epigenetics and apoptosis” |
| 2004 – present | Lectures and practicals of BSc and MSc degree Molecular Biology students in the summer semester courses “Cellular Regulatory Mechanisms” at the Department of Cytology, Faculty of Biology, Sofia University |
| 1994 – present | Union of Scientists in Bulgaria |
| 1994 – present | FEBS constituent society |
| 2002 – present | Мember of The Finance and Policy Committee of ICYGMB - a yeast molecular biology organization (Bulgarian representative) |
| 2016 | Staneva, D., Georgieva, M. and Miloshev, G. 2016 Klyuveromices lactis harbours a functional linker histone encoding gene FEMS Yeast Res, Volume 16 (4), April 2016, Pages 182-192 |
| 2016 | Vasileva, B., Georgieva, M., Staneva, D., Zagorchev, P. and Miloshev, G. 2016 Chromatin modulates cellular response to UV light during the process of chronological ageing International Comptes Rendus de l'Academie Bulgare de Sciences , Volume 69 (12), Pages1592-1602 |
| 2016 | Georgieva, M., Staneva, D. and Miloshev, G. Epigenetic significance of chromatin during cellular ageing and organismal lifespan In D. Hollar and D. Vasudevan (Eds.) Epigenetics, the environment and children's health across lifespans, New York, Springer, pp 21-66, ISBN: 978-3-319- 25323-7. |
| 2015 | Georgieva, M., Staneva, D., Uzunova, K., Efremov, T., Balashev, K., Harata, M. Miloshev, G. The linker histone in Saccharomyces cerevisiae interacts with actin-related protein 4 and both regulate chromatin structure and cellular morphology International Journal of Biochemistry and Cell Biology, Volume 59, February 2015, Pages 182-192 |
| 2014 | Kazakova, M.H., Staneva, D.N., Koev, I.G., Staikov, D.G., Mateva, N., Timonov, P.T., Miloshev, G.A., Sarafian, V.S. Protein and mRNA levels of YKL-40 in high-grade glioma Folia Biologica, Volume 60, Issue 6, 2014, Pages 261-267 |
| 2014 | Miloshev, G.A., Peycheva, E.N., Dodoff, N.I., Kushev, D.N., Lalia-Kantouri, M. Effect of light transition metal complexes of methanesulfonic acid hydrazide on the viability of yeast Saccharomyces cerevisiae Molecular and Cellular Probes, Volume 28, Issue 5-6, 1 October 2014, Pages 259-263 |
| 2014 | Ekaterina Peycheva, Radostina Alexandrova, George Miloshev Application of the yeast comet assay in testing of food additives for genotoxicity LWT - Food Science and Technology, Volume 59, Issue 1, November 2014, Pages 510-517 |
| 2013 | Setchanova, L., Kostyanev, T., Markovska, R., Miloshev, G., Mitov, I.G. 2013. Serotypes, antimicrobial susceptibility, and beta-lactam resistance mechanisms of clinical Haemophilus influenzae isolates from Bulgaria in a pre-vaccination period. Scandinavian J. Infect . Diseases. 45, 2013, 81-87 |
| 2012 | Staneva, D., Peycheva, E., Georgieva, M., Efremov, T. and Miloshev, G. 2012. Application of comet assay for the assessment of DNA damage caused by chemical genotoxins in the dairy yeast Kluyveromyces lactis. Antonie van Leeuwenhoek. 08/2012; DOI:10.1007/s10482-012-9793-0 |
| 2012 | Alexandrova, R.I., Zhivkova, T., Alexandrov, M., Miloshev, G., Georgieva, M., Pantcheva I.,Mitewa, M. 2012. Cytostatic and cytotoxic properties of Monensic acid and its biometal(II) complexes against human tumor/ non-tumor cell lines. Central European Journal of Chemistry (in press) |
| 2012 | Peycheva, E., Tashev, A., Vasileva, Y., Staneva, D., Georgieva, M., Miloshev, G. 2012. Genome rearrangements in the common dandelion Taraxacum officinale web. collected from sites polluted with heavy metals. Comptes Rendus de l’Academie Bulgare, des Sciences, 65 (6): 807 – 814 |
| 2012 | Georgieva M., Miloshev G. 2012. The linker histone and chromatin of yeast Saccharomyces cerevisiae. In: Histones: Class, Structureand Function (Chang-Hui Shen, ed.), Nova Science Publishers, NY, USA (2011) pp. 59-75, ISBN: 978-1-62100-274-1 |
| 2012 | George Miloshev, Ekaterina Peycheva, Milena Georgieva. 2012. A sensitive method detects DNA damages caused by food additives. Journal of Bulgarian Academy of Sciences, vol. 1, 10-14., ISSN 0007-3989 |
| 2011 | Georgieva M., Staneva D., Uzunova K. and Miloshev G. 2011. The deletion of the gene for the linker histone in arp 4 mutant yeast cells is not deleterious. Biotechnology and Biotechnological Equipment, 26 134 – 139 |
| 2011 | Georgieva M., Roguev A., Balashev K., Zlatanova J., Miloshev G. 2011. Hho1p, the linker histone of Saccharomyces cerevisiae, is important for the proper chromatin organization in vivo. Biophys. Biochem.Acta Gen. Reg. Mechanisms, 1819 (5): 366-374 |
| 2011 | Peycheva, E. , Ivanova, E. , Ivanov, S., Miloshev, G. (2011) Improved procedure for comet assay on active photosynthetic cells from pea plants. Oxidation Communications, 34 (2), pp. 320-325 |
| 2010 | M. Draganov, G. Miloshev, N. Popov, M. Murdjeva, D. Staneva, M. Kostova, D. Draganov and N. Tomlekova. 2010. Molecular and cytogenetic criteria for identification of serum-free cell cultures. Biotechnology & Biotechnological Equipment 24(2) Special Edition, pp. 139-143. ISSN 1310-2818 |
| 2009 | Miteva, R., Georgieva, M., Peycheva, E., Efremov, T., Miloshev, G. 2009. Development of conditions for comet assay application in forensic investigation of rape and other sexual assaults. Biotechnology and Biotechnological Equipment 23 (1), pp. 1093-1094 |
| 2009 | Peycheva, E., Georgieva, M., Miloshev, G. 2009. Comparison between alkaline and neutral variants of yeast comet assay. Biotechnology and Biotechnological Equipment 23 (1), pp. 1090-1092 |
| 2009 | Georgieva, M., Efremov, T., Alexandrova, R. and Miloshev, G. 2009. Comet Assay discriminates levels of chromatin compaction, Comptes Rendus de L'Academie Bulgare des Sciences 62 (4), pp. 479-484 |
| 2008 | Georgieva, M., Harata, M. and Miloshev, G. The nuclearactin-related protein Act3p/Arp4 influences yeast cell shape and bulk chromatin organization, J Cellular Biochem, 2008 May 1;104(1): 59-67 |
| 2008 | D. Staneva, D. Uccelletti, P. Venkov, G. Milolshev, C. Palleschi. (2008) The Kluyveromyces lactis CPY Homologous Genes – Cloning and Characterization of the KlPCL1 Gene. Folia Microbiol. 53 (4), 325–332 |
| 2008 | Draganova-Filipova, M., Georgieva, M., Peycheva, E., Miloshev, G., Sarafian, V. and Peychev, P. 2008. Effects of propolis and CAPE on proliferation and apoptosis of McCoy-Plovdiv cell line. Folia Medica 1: 53-59 |
| 2007 | Alexandrova, R., Vacheva, A., Georgieva, M., Miloshev, G., Mosoarca, E.M., Tudose, R. and Costisor, O. 2007. Investigations on cytotoxic and antiproliferative effects in vitro of a newly synthesized mixed ligand copper (II) complex, Acta Morphologica et Anthropologica, 12: 72-78 |
| 2007 | Lesseva, M., Christova, I., Miloshev, G. 2007 Cloning and expression of recombinant flagellar protein flaB from Borrelia burgdorferi. Folia medica, 49 (3-4), pp. 58-62 |
